Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor.

Liwei Wang*, Catherine Hall*, Jie Li, Eunhee Choi†, Xiao-chen Bai†. Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor. Nature Structural & Molecular Biology. 2023.

Sensory specializations drive octopus and squid behaviour.

Guipeun Kang*, Corey AH Allard*, Wendy A Valencia-Montoya*, Lena van Giesen, Jeong Joo Kim, Peter B Kilian, Xiao-chen Bai, Nicholas W Bellono†, Ryan E Hibbs†. Sensory specializations drive octopus and squid behaviour. Nature. 2023.

Inhibition of FAM46/TENT5 activity by BCCIPα adopting a unique fold.

Shun Liu*, Hua Chen*, Yan Yin*, Defen Lu, Guoming Gao, Jie Li, Xiao-chen Bai†, Xuewu Zhang†. Inhibition of FAM46/TENT5 activity by BCCIPα adopting a unique fold. Science Advances. 2023.

The Activation Mechanism of the Insulin Receptor: A Structural Perspective.

Eunhee Choi†, Xiao-chen Bai†. The Activation Mechanism of the Insulin Receptor: A Structural Perspective. Annual Review of Biochemistry. 2023.

Molecular basis for the role of disulfide-linked αCTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.

Jie Li, Jiayi Wu, Catherine Hall, Xiao-chen Bai†, Eunhee Choi†. Molecular basis for the role of disulfide-linked αCTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. eLife. 2022.

Activation of the insulin receptor by an insulin mimetic peptide.

Junhee Park*, Jie Li*, John P Mayer, Kerri A Ball, Jiayi Wu, Catherine Hall, Domenico Accili, Michael HB Stowell, Xiao-chen Bai†, Eunhee Choi†. Activation of the insulin receptor by an insulin mimetic peptide. Nature Communications. 2022.

Beth Levine. Structural basis for gating mechanism of the human sodium-potassium pump.

Phong T Nguyen†, Christine Deisl, Michael Fine, Trevor S Tippetts, Emiko Uchikawa, Xiao-chen Bai†, Beth Levine. Structural basis for gating mechanism of the human sodium-potassium pump. Nature Communications. 2022.

An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif.

Yan Fang*, Pengcheng Sun*, Xuping Xie, Mingjian Du, Fenghe Du, Jianfeng Ye, Birte K Kalveram, Jessica A Plante, Kenneth S Plante, Bo Li, Xiao-chen Bai, Pei-Yong Shi†, Zhijian J Chen†. An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif. Science immunology. 2022.

Synergistic activation of the insulin receptor via two distinct sites. Nature Structural & Molecular Biology.

Jie Li, Junhee Park, John P. Mayer, Kristofor J. Webb, Emiko Uchikawa, Jiayi Wu, Shun Liu, Xuewu Zhang, Michael H.B. Stowell†, Eunhee Choi†, Xiao-chen Bai†. Synergistic activation of the insulin receptor via two distinct sites. Nature Structural & Molecular Biology. 2022.

Activation of human STING by targeting a pocket in the transmembrane domain.

Defen Lu*, Guijun Shang*, Jie Li , Yong Lu , Xiao-chen Bai†, Xuewu Zhang†. Activation of human STING by targeting a pocket in the transmembrane domain. Nature. 2022.