C-MET/HGF 2:2 asymmetric complexes in the active state. This study reveals that one HGF molecule is sufficient to induce a specific dimerization mode of c-MET by utilizing two distinct interfaces

September 21, 2018/by Academic Web Pages

Scap alone or with Insig bound. This study reveals a large rotation of the luminal L1-L7 domain upon the binding of Scap to Insig.

September 22, 2018/by Academic Web Pages

Sema3A/PlexinA4/Neuropilin tripartite complex

September 23, 2018/by Academic Web Pages

STRIPAK complex: a large, multisubunit protein phosphatase 2A assembly that is critical in regulating the Hippo pathway

September 24, 2018/by Academic Web Pages

SARM1 in the auto-inhibited state

September 25, 2018/by Academic Web Pages

Human ZnT8, a Zn2+/H+ antiporter in the insulin secretory granules, determined in the inward-facing conformation. This study provides the structural insights into the Zn2+/H+ exchange mechanism of ZnT8

September 26, 2018/by Academic Web Pages

Human cohesin bound to its loader NIPBL and DNA

September 27, 2018/by Academic Web Pages

PlexinC1/A39R 2:2 dimeric complex

September 28, 2018/by Academic Web Pages

Human KCC1 determined in inward-facing conformation

September 29, 2018/by Academic Web Pages

IGF1R dimer with one IGF1 bound in an asymmetric, active conformation

September 30, 2018/by Academic Web Pages

Four different RET signalling complexes

Cryo-EM structures of the extracellular region ternary complexes…
September 1, 2019/by Academic Web Pages

Insulin receptor with four insulins bound

This is the first high resolution structure of IR-insulin complex…
September 2, 2019/by Academic Web Pages

Human mitochondrial calcium uniporter bound with EMRE

September 3, 2019/by Academic Web Pages

The proton channel OTOP3

The cryo-EM structure of OTOP3 from Xenopus tropicalis (XtOT…
September 4, 2019/by Academic Web Pages

The human TPC2 channel in both closed and open states

September 5, 2019/by Academic Web Pages

STING bound with TBK1

The structure reveals that the C-terminal tail of STING is bound…
September 6, 2019/by Academic Web Pages

The full-length STING in both apo and CGAMP bound states

A 80 kDa membrane protein was determined by cryo-EM
September 7, 2019/by Academic Web Pages

The fungal mitochondrial calcium uniporter

The cryo-EM structure was determined by using the Volta phase…
September 8, 2019/by Academic Web Pages

The mammalian TPC1 channel in both closed and open states

These structures reveal how phosphoinositide activate the ion…
September 9, 2019/by Academic Web Pages

The calcium-activated, non-selective cation channel TRPM4

September 10, 2019/by Academic Web Pages

The endolysosomal TRPML1 channel in nanodiscs

The first structure determined using the UTSW’s new $17 million…
September 11, 2019/by Academic Web Pages

The Plasmodium falciparum 80S ribosome bound to the drug Mefloquine

September 12, 2019/by Academic Web Pages

The rabbit RyR1 in open conformation

September 13, 2019/by Academic Web Pages

Masked classification with residual signal subtraction

A method of dealing with local structural heterogeneity
September 14, 2019/by Academic Web Pages

The γ-secretase in complex with DAPT

September 15, 2019/by Academic Web Pages

The human γ-secretase

The first high resolution cryo-EM structure of γ-secretase
September 16, 2019/by Academic Web Pages

The Dark apoptosome

The apoptosome from Drosophila
September 17, 2019/by Academic Web Pages

The rabbit ryanodine receptor RyR1 in closed state

September 18, 2019/by Academic Web Pages

The Plasmodium falciparum 80S ribosome bound to the drug emetine

September 19, 2019/by Academic Web Pages

The yeast mitochondrial large ribosomal subunit

The first high resolution cryo-EM structure of mitochondrial…
September 20, 2019/by Academic Web Pages

The yeast eIF5B initiation complex

Determining a relatively high-resolution structure of the eIF5B-ribosome…
September 21, 2019/by Academic Web Pages

Movie processing

Approach to compensate for beam-induced particles movement
September 22, 2019/by Academic Web Pages

3D DNA-origami object

September 23, 2019/by Academic Web Pages