
C-MET/HGF 2:2 asymmetric complexes in the active state. This study reveals that one HGF molecule is sufficient to induce a specific dimerization mode of c-MET by utilizing two distinct interfaces
September 21, 2018/by Academic Web PagesScap alone or with Insig bound. This study reveals a large rotation of the luminal L1-L7 domain upon the binding of Scap to Insig.
September 22, 2018/by Academic Web PagesSema3A/PlexinA4/Neuropilin tripartite complex
September 23, 2018/by Academic Web PagesSTRIPAK complex: a large, multisubunit protein phosphatase 2A assembly that is critical in regulating the Hippo pathway
September 24, 2018/by Academic Web PagesSARM1 in the auto-inhibited state
September 25, 2018/by Academic Web PagesHuman ZnT8, a Zn2+/H+ antiporter in the insulin secretory granules, determined in the inward-facing conformation. This study provides the structural insights into the Zn2+/H+ exchange mechanism of ZnT8
September 26, 2018/by Academic Web PagesHuman cohesin bound to its loader NIPBL and DNA
September 27, 2018/by Academic Web PagesPlexinC1/A39R 2:2 dimeric complex
September 28, 2018/by Academic Web PagesHuman KCC1 determined in inward-facing conformation
September 29, 2018/by Academic Web PagesIGF1R dimer with one IGF1 bound in an asymmetric, active conformation
September 30, 2018/by Academic Web PagesFour different RET signalling complexes
Cryo-EM structures of the extracellular region ternary complexes…
September 1, 2019/by Academic Web PagesInsulin receptor with four insulins bound
This is the first high resolution structure of IR-insulin complex…
September 2, 2019/by Academic Web PagesHuman mitochondrial calcium uniporter bound with EMRE
September 3, 2019/by Academic Web PagesThe proton channel OTOP3
The cryo-EM structure of OTOP3 from Xenopus tropicalis (XtOT…
September 4, 2019/by Academic Web PagesThe human TPC2 channel in both closed and open states
September 5, 2019/by Academic Web PagesSTING bound with TBK1
The structure reveals that the C-terminal tail of STING is bound…
September 6, 2019/by Academic Web PagesThe full-length STING in both apo and CGAMP bound states
A 80 kDa membrane protein was determined by cryo-EM
September 7, 2019/by Academic Web PagesThe fungal mitochondrial calcium uniporter
The cryo-EM structure was determined by using the Volta phase…
September 8, 2019/by Academic Web PagesThe mammalian TPC1 channel in both closed and open states
These structures reveal how phosphoinositide activate the ion…
September 9, 2019/by Academic Web PagesThe calcium-activated, non-selective cation channel TRPM4
September 10, 2019/by Academic Web PagesThe endolysosomal TRPML1 channel in nanodiscs
The first structure determined using the UTSW’s new $17 million…
September 11, 2019/by Academic Web PagesThe Plasmodium falciparum 80S ribosome bound to the drug Mefloquine
September 12, 2019/by Academic Web PagesThe rabbit RyR1 in open conformation
September 13, 2019/by Academic Web PagesMasked classification with residual signal subtraction
A method of dealing with local structural heterogeneity
September 14, 2019/by Academic Web PagesThe γ-secretase in complex with DAPT
September 15, 2019/by Academic Web PagesThe human γ-secretase
The first high resolution cryo-EM structure of γ-secretase
September 16, 2019/by Academic Web PagesThe Dark apoptosome
The apoptosome from Drosophila
September 17, 2019/by Academic Web PagesThe rabbit ryanodine receptor RyR1 in closed state
September 18, 2019/by Academic Web PagesThe Plasmodium falciparum 80S ribosome bound to the drug emetine
September 19, 2019/by Academic Web PagesThe yeast mitochondrial large ribosomal subunit
The first high resolution cryo-EM structure of mitochondrial…
September 20, 2019/by Academic Web PagesThe yeast eIF5B initiation complex
Determining a relatively high-resolution structure of the eIF5B-ribosome…
September 21, 2019/by Academic Web PagesMovie processing
Approach to compensate for beam-induced particles movement
September 22, 2019/by Academic Web Pages3D DNA-origami object
September 23, 2019/by Academic Web PagesMap
Bai Lab
UT Southwestern Medical Center
5323 Harry Lines Boulevard
Dallas, TX 75390
Xiaochen.Bai@utsouthwestern.edu