Insulin receptor with four insulins bound

This is the first high resolution structure of IR-insulin complex determined by using a full-length IR. This structure reveals the insulin binding site 2.

Four different RET signalling complexes

Cryo-EM structures of the extracellular region ternary complexes of GDF15/GFRAL/RET, GDNF/GFRα1/RET, NRTN/GFRα2/RET and ARTN/GFRα3/RET.