Human mitochondrial calcium uniporter bound with EMRE

Insulin receptor with four insulins bound

This is the first high resolution structure of IR-insulin complex determined by using a full-length IR. This structure reveals the insulin binding site 2.

Four different RET signalling complexes

Cryo-EM structures of the extracellular region ternary complexes of GDF15/GFRAL/RET, GDNF/GFRα1/RET, NRTN/GFRα2/RET and ARTN/GFRα3/RET.

Human KCC1 determined in inward-facing conformation

PlexinC1/A39R 2:2 dimeric complex

Human cohesin bound to its loader NIPBL and DNA

Human ZnT8, a Zn2+/H+ antiporter in the insulin secretory granules, determined in the inward-facing conformation. This study provides the structural insights into the Zn2+/H+ exchange mechanism of ZnT8

SARM1 in the auto-inhibited state